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Here's a shot of Halwin running as a window on my OSX desktop:
And here's a shot of using OSX's built in spaces and VMWare Fusion, running OSX in the top left, Ubuntu linux in the top right, and Windows Vista in the bottom left:
Dapplegrey and DOSBox make running the e6k and e6x DOS apps from OS X pretty easy. apple.com/downloads has a driver for a bunch of the USB-Serial dongles too.